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AllerMAbs.jpg

艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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Cellular Dynamics.jpg

Cellular Dynamics公司可以大规模从干细胞诱导分化生产人类细胞,用于基础研究,药物发现和再生医学应用。CDI提供了几种末分化的细胞种类作为目录产品:iCell心肌细胞,iCell神经元,iCell内皮细胞和iCell肝细胞。 CDI的MyCell®产品组合能够为客户提供的供体样品进行重编程,基因编辑和分化。该公司还有几种来源于多能干细胞的原型产品,包括iCell心脏祖细胞,iCell造血祖细胞,iCell星形胶质细胞和iCell骨骼成肌细胞等。

 

Fujifilm, once a Company whose core business was photographic film, has diversified and strengthened its portfolio based on developing or acquiring proprietary technologies as well as a deeply held corporate philosophy of enhancing the quality of human lives worldwide. One key area of focus for the Company is Healthcare, and Fujifilm acquired Cellular Dynamics International in May 2015, renamed it to FUJIFILM Cellular Dynamics, Inc.(FCDI) in 2018 to drive innovation in this business area. We see great potential in FCDI as a key component in our mission to be the global leader in regenerative medicine and drug discovery through cutting-edge science and technology.

 

To date FCDI has already achieved leadership in the induced pluripotent stem cell (iPSC) field as one of the only companies in the world to industrially manufacture human cells derived from iPSCs with high quality, purity, and reproducibility and in virtually unlimited quantities. Not only have we achieved this across multiple healthy and diseased donors for the research market but also, we have begun to manufacture human cells under cGMP conditions – a requirement as these human cellular products move from a tool used in drug discovery into a therapy used in regenerative medicine applications.

 

Cellular Dynamics公司的主要产品包括:

iCell Cardiomyocytes

iCell Cardiac Progenitor Cells

iCell Neurons

iCell Astrocytes

iCell DopaNeurons

iCell Hepatocytes 2.0

iCell Hepatoblasts

iCell Skeletal Myoblasts

iCell Endothelial Cells

iCell Hematopoietic Progenitor Cells

iCell Macrophages

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Mediomics.jpg

Mediomics公司2001年成立,致力于为学术机构、制药公司、医学研究者、环境研究者提供创新性的检测试剂盒及生物感应物质。Mediomics拥有Patented Bridge-It® Assay Platform、Patented FRET-PINCER® Assay Platform、Patented TRF-PINCER® Assay Platform三大技术平台。

 

Mediomics, LLC provides innovative assay kits and biosensors needed by academic research laboratories, point of care testing, pharmaceutical companies, as well as medical and environmental research markets.  

 

Technology platforms:

(1)Patented Bridge-It® Assay Platform

Bridge-It® Assays are optimized to measure DNA binding proteins, their ligands, and co-regulators. Mediomics’ Bridge-It® assay was based on a simple idea of splitting the DNA binding site for a protein into two DNA half-sites. The presence of the DNA-binding protein or one of its ligands can be detected by FRET (fluorescence resonance energy transfer).

(2)Patented FRET-PINCER® Assay Platform

FRET-PINCER® Assays are a unique system to quantify the concentration of biomarkers, cells, and pathogens in a broad range of biological samples. The patent-protected FRET-PINCER® Assay system detects the concentration of the target molecule by bringing together complementary single-stranded DNAs and their attached fluorophores to produce fluorescent light through FRET (fluorescence resonance energy transfer).

(3)Patented TRF-PINCER® Assay Platform

TRF-PINCER® Assays are a unique system to quantify the concentration of biomarkers, cells, and pathogens in a broad range of biological samples. The patent-protected TRF-PINCER® Assay platform system detects the concentration of the target molecule by bringing together complementary single-stranded DNAs and their attached fluorophores to produce fluorescent light with Time-Resolved Fluorometry (TRF) sensitivity.

 

主要产品线包括:

(1)Bridge-It® Assay

(2)TR-FRET Bridge-It® Assay

(3)FRET-PINCER® Assay

(4)TR-FRET PINCER®Assay

(5)Other

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全国服务热线:400-6800-868

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Polymer Source.jpg

Polymer Source公司成立于1994年,致力于为世界范围的客户提供高品质的Deuterated Polymers 氘代聚合物和Protonated Polymers质子化聚合物。

 

Since its inception in 1994, Polymer Source Inc. takes great pride in supplying a high quality of architecturally controlled specialty polymers in the world of research and development. Our research team comprises of dynamic, competent and innovative scientists who excel in supplying top class service to various research institutions. Within a span of six years our team has accomplished the production of over 3000 block copolymers that have gained worldwide recognition.


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Polymer Source公司的主要产品包括:

Deuterated Homopolymers 氘代均聚物

Deuterated Block Copolymers 氘代嵌段共聚物

Deuterated Functionlized Polymers 氘代功能聚合物

Deuterated Random and Alternating Copolymers 氘代无规和交替共聚物

Deuterated Monomers 氘代单体

Deuterated Oligomers (Dimer & Trimer etc.) 氘代齐聚物(二聚物和三聚物等)

C13 Labeled Polymers C13标示聚合物

Monomers-High Purity 高纯单体

Hydrophobic Polymers 憎水聚合物

Hydrophilic Polymers 亲水聚合物

Diblock Copolymers 双嵌段共聚物

Amphiphilic Block Copolymers 两性嵌段共聚物

A-B-A Triblock Copolymers A-B-A三嵌段共聚物

A-B-C Triblock Copolymers A-B-C三嵌段共聚物

Random and Alternating Copolymers 无规和交替共聚物

Functionalized Polymers 功能聚合物

Star-like Polymers 星形聚合物

Comb-like Polymers 梳子形聚合物

Labeled Polymers 标示聚合物

Ionomers 离子聚合物

Oligomers (Dimer & Trimer etc.) 齐聚物(二聚物和三聚物等)

Conducting and Luminescence Polymers 导电和荧光聚合物 

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全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com


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艾美捷科技代理Trialtusbioscience品牌全系列产品


TriAltus Bioscience是一个致力于为推动人类健康前沿的科学家服务的品牌。当今的创新者在推进基因疗法、工程诊断、早期疾病检测以及药物发现等领域,都需要高纯度、高性能且随时可以扩展的酶,TriAltus正是为此而存在。TriAltus的核心是其专有的CLiM™(CL7/Im7)纯化平台,是一种基于亲和标签的突破性系统,能在单个色谱步骤中提供具有卓越纯度、活性和一致性的酶,重新定义了重组蛋白纯化的可能性。 使用CLiM™生产的每种酶都以严格的质量控制、批次间一致性和详细的分析证书(COA)为后盾,旨在满足监管机构要求的质量和文档标准,支持从发现到扩大规模的更平稳过渡。TriAltus Bioscience公司的产品包括:基因组酶、蛋白酶和其他酶。


TriAltusBioscience页面.png


Trialtusbioscience产品线

● 基因组酶:TriAltus的重组基因组酶不含标签,并使用专有的CLiM™亲和标签系统进行纯化,提供目录酶的定制缩放和配方,以满足特定研究需求,无论需要更高的浓度、独特的缓冲条件还是批量生产,都可以根据具体规格定制酶。


货号品名规格产品描述
40-1212AapCas12b Protein20 μgexpressed in E. coli and features two C-terminal nuclear localization signals,enables the inactive nuclease to be guided to the specific double stranded DNA site.
40-1220AapCas12b Protein100 μg
40-1225AapCas12b Protein500 μg
40-1320CRISPR-Cas9 Protein100 μgused for genome editing with CRISPR technology. Recombinant Streptococcus pyogenes Cas9 ,expressed in Escherichia coli and features two nuclear localization signals
40-1325CRISPR-Cas9 Protein500 μg
40-2414Phi29 DNA Polymerase3,000 Unitsa highly processive, isothermal enzyme from Bacillus subtilis phage phi29 ,with a robust 3'→5' proofreading exonuclease function.
40-2420Phi29 DNA Polymerase10,000 Units
40-2125TAT-CRE Recombinase500 μgused for site-specific DNA recombination in mammalian cells,a fusion protein combining a nuclear localization sequence, HIV-TAT cell permeabilization peptide, and Cre recombinase.
40-2130TAT-CRE Recombinase1 mg
40-2135TAT-CRE Recombinase5 mg


● 蛋白酶和其他酶:例如为冷冻电镜生成蛋白质的实验室提供SUMO蛋白酶,去除相关标签后蛋白质可进行分析,反应高效、稳健,无需优化,客户对酶的性能和优质客户服务感到满意。


货号品名规格产品描述
30-2130PreScission Protease1 mgrecognizes and cleaves the sequence LEVLFQ/GP  to release the target protein from the Im7-bound CL7 tag
30-2135PreScission Protease5 mg
30-2140PreScission Protease10 mg
30-2146PreScission Protease50 mg
30-2150PreScission Protease100 mg
30-1130SUMO Protease1 mgreleases target proteins from TriAltus’s Im7 resin,recognizes SUMO tertiary structure – not a specific amino acid sequence – to cleave and release the target protein from the Im7-bound CL7 tag.
30-1135SUMO Protease5 mg
30-1140SUMO Protease10 mg
30-1146SUMO Protease50 mg
30-1150SUMO Protease100 mg



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